Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis
نویسندگان
چکیده
منابع مشابه
Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis
OBJECTIVE Identify gene changes in articular cartilage of the medial tibial plateau (MTP) at 2, 4 and 8 weeks after destabilisation of the medial meniscus (DMM) in mice. Compare our data with previously published datasets to ascertain dysregulated pathways and genes in osteoarthritis (OA). DESIGN RNA was extracted from the ipsilateral and contralateral MTP cartilage, amplified, labelled and h...
متن کاملPost-traumatic Erosions of Articular Cartilage.
Erosions of articular cartilage are often seen in the knee joint in association with certain internal derangements such as meniscus tears or after recurrent subluxation of the patella (Helfet 1959, Smillie 1962). Also a number of studies have appeared on the pathology of articular cartilage after injury, both in man (Landells 1957) and in experimental animals (Barnett 1956. Tallqvist 1962, Meac...
متن کاملPathology of the Calcified Zone of Articular Cartilage in Post-Traumatic Osteoarthritis in Rat Knees
OBJECTIVES This study aimed to investigate the pathology occurring at the calcified zone of articular cartilage (CZC) in the joints afflicted with post-traumatic osteoarthritis (PTOA). METHODS Rats underwent bilateral anterior cruciate ligament (ACL) transection and medial meniscectomy to induce PTOA. Sham surgery was performed on another five rats to serve as controls. The rats were euthaniz...
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INTRODUCTION Recent studies have revealed that rapamycin activates autophagy in human chondrocytes preventing the development of osteoarthritis (OA) like changes in vitro, while the systemic injection of rapamycin reduces the severity of experimental osteoarthritis in a murine model of OA in vivo. Since the systemic use of rapamycin is associated with numerous side effects, the goal of the curr...
متن کاملEffect of passive motion on articular cartilage in rat osteoarthritis
The aim of the present study was to investigate the effect of moderate passive motion on articular cartilage in osteoarthritis (OA) caused by knee fracture. Sprague-Dawley rats (age, 8 weeks) with knee fractures were used to construct rat knee early- and middle-stage OA models. The stages were fixed for three and six weeks, with 20 rats analyzed at each stage. The experimental groups were exerc...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2015
ISSN: 1063-4584
DOI: 10.1016/j.joca.2014.12.014